After Sen. Lindsey Graham's death in July, his sister Darline Graham was appointed to the seat and won a special Republican runoff to replace him on the ballot. Democrat Annie Andrews is running in a state that hasn't sent a Democrat to the Senate since 1998. Get caught up ↓

Charleston pediatrician making her first Senate run; ran for Congress in 2022.
Campaign website →Appointed senator and Lindsey Graham's sister. Beat Rep. Ralph Norman in the August 25 runoff with 52.5% of the vote, with Trump's endorsement. Had never run for office; previously led a state agency serving blind South Carolinians.
Graham leads Andrews 47.6% to 43.9% in the Pollsmax average of five polls (as of early September). Trump won South Carolina by 18 points in 2024.
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Where each candidate stands on campaign-finance questions.
Sources: Andrews joins End Citizens United’s program: no corporate PACs, stock-trading ban
Campaign committee totals for the 2025–26 cycle. Under-$200 share is unitemized individual contributions divided by total receipts. FEC filings →
Graham's positions will be added once sourced.